Pathway Abortus. Abstract In epithelial cells the intracellular pathogen Brucella abortus escapes from the endocytic pathway exploits the autophagic machinery of the host cell and establishes a unique replication niche in the endoplasmic reticulum The molecular mechanisms underlying these processes are still poorly understood.
IntroductionMaterials and MethodsResultsDiscussionConclusionData Availability StatementAuthor ContributionsFundingConflict of InterestSupplementary MaterialBrucella infects animals and human beings and causes Brucellosis (Atluri et al 2011) a major zoonotic disease endemic in more than 170 countries and regions of the world (Avilacalderon et al 2013) Brucellosis is classified as an important reemerging disease of humans and animals in China (Zhou et al 2020) where it has shown an upward trend in recent years (Zheng et al 2018.
B. abortus RNA is the component involved in the down
the present study demonstrates that brucella abortus infection induces the activation of the autophagic pathway in hepatic stellate cells to create a microenvironment that promotes a profibrogenic phenotype through the induction of transforming growth factorβ1 (tgfβ1) collagen deposition and inhibition of matrix metalloproteinase9 (mmp9).
Brucella abortus transits through the autophagic pathway
Pathway Kelainan zigot Kelainan hormonal Gangguan Embrio tidak bisa berkembang nutrisi Penyakit infeksi Kelainan imunologik Factor psikologis Kelainan anatomic uterus Pertubuhan janin intra uteri tidak sempurna Gangguan fungsi endometrium Gangguan implantasi hasil konsepsi Gangguan pertumbuhan mudigah Abortus.
Brucella abortus Triggers a cGASIndependent STING Pathway
In macrophages B abortus can install phosphatidylcholine to its outer membrane and can synthesize cyclic β12glucans that interact with the lipid rafts leading to preventing phagolysosome fusion event ( Reyes et al 2017 ).
